Nature Biotechnology | 2023
Recording of cellular physiological histories along optically readable self-assembling protein chains
Changyang Linghu, Bobae An, Monika Shpokayte, Orhan T. Celiker, Nava Shmoel, Ruihan Zhang, Chi Zhang, Demian Park, Won Min Park, Steve Ramirez and Edward S. Boyden
Summary: biological information over time, such as gene expression history, can be recorded onto the ordered structure of intracellular protein self-assembly for scalable readout in large cell populations.
Methods in Molecular Biology | 2022
Single-cell resolution optogenetics via expression of soma-targeted rhodopsins
Changyang Linghu, I-Wen Chen, Dimitrii Tanese, Valeria Zampini and Or A. Shemesh
Summary: methods for temporally precise single-cell resolution optogenetics in tissue and in the living brain.